human leukocyte antigen b27 in 453 asian indian patients with seronegative spondyloarthropathy

نویسندگان

mahendra narain mishra

department of pathology, command hospital (sc) vinay singai

department of internal medicine and rheumatology, command hospital (sc), pune, india

چکیده

background: spondyloarthropathies are a group of closely related inflammatory arthritis which involve the axial skeleton and are negative for rheumatoid factor. objective: this case-control study was conducted to examine hla- b27 positivity in patients with seronegative spondyloarthritis (ssa) as per essg criteria and compare the frequency with healthy controls because a lower positivity is reported in indians. method: the study included 453 patients and 200 controls. hla -b27 typing was done by microlymphocytoxicity and/or by sequence specific primers (ssp) using commercial kits. patients were categorised as ankylosing spondylitis (as), undifferentiated spondyloarthropathy, ssa with inflammatory bowel disease, reactive arthritis, psoriatic arthritis and juvenile spondyloarthropathy. results: hla-b27 antigen was present in 56% of patient and 3.5% controls with highest frequency in juvenile spondyloarthropathy (80%), followed by as (76%). the p value < 0.001 for all categories of ssa and overall odds ratio was 34.9. conclusion: this study showed hla-b27 frequency slightly lower than reported in caucasian ssa patients and in our opinion hla- b27 testing is extremely useful in young patients with suspected ssa.

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عنوان ژورنال:
iranian journal of immunology

جلد ۷، شماره ۴، صفحات ۲۵۲-۲۵۶

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